Co-Stimulation–Induced AP-1 Activity is Required for Chromatin Opening During T Cell Activation

Abstract excerpt

Activation of T cells is dependent on organized and timely opening and closing of chromatin. Herein, we identify AP-1 as the transcription factor that directs most of this remodeling. Chromatin accessibility profiling showed quick opening of closed chromatin in naïve T cells within 5 hours of activation. These newly open regions were strongly enriched for the AP-1 motif, and indeed, ChIP-seq demonstrated AP-1 bind...

Topics

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• Gene Expression
• Genes, MHC Class II
• HIV-1
• HIV Infections
• Immune System
• NF-κB Signaling Pathways
• Signaling Pathways in Disease
• Transcriptional Activation

Identifiers and source

Literature Corpus work

e8133298-21cc-5d1f-8eec-249584ead993

DOI

10.1101/647388