Article

Human spinal cord organoids recapitulate developmental and disease-associated oligodendrocyte lineage signatures

2026-05-01

Abstract excerpt

Oligodendrocytes play essential roles in central nervous system development and homeostasis, and their dysfunction is a hallmark of numerous neurological disorders. However, human in vitro systems that support oligodendrocyte lineage progression while enabling the study of disease-relevant states remain limited. Here, we establish human spinal cord organoids (hSpO) and cortico-motor assembloids as platforms to mod...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 581291dd-44d1-5529-85c0-943fe892b829
DOI: 10.64898/2026.04.28.721458

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human spinal cord organoids recapitulate developmental and disease-associated oligodendrocyte lineage signaturesDOI 10.64898/2026.04.28.721458Read

A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis.Semantic proximity Read

A Human iPSC-derived Organoid System to Model Myelin Destruction and RepairSemantic proximity Read

Glia-enriched stem-cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosisSemantic proximity Read

Synchronous 3D patterning of diverse CNS progenitors generates motor neurons of broad axial identitySemantic proximity Read

Diversity of Adult Neural Stem and Progenitor Cells in Physiology and DiseaseSemantic proximity Read

DEVELOPMENT OF ORGANOID BASED MODEL TO STUDY IMMUNE-NEURAL INTERACTIONS IN HUMAN CNS DISEASESSemantic proximity Read

Distinct oligodendrocyte populations have spatial preference and injury-specific responsesSemantic proximity Read

Rapid and efficient generation of human oligodendrocytes myelinating adult human cortical neuronsSemantic proximity Read

Efficient generation of human oligodendrocyte grafts that restore myelin in adult human brain tissueSemantic proximity Read

SOX10 Single Transcription Factor-Based Fast and Efficient Generation of Oligodendrocytes from Human Pluripotent Stem CellsSemantic proximity Read

Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells.Semantic proximity Read

Stage-specific exposure to an activity-permissive media enhances neuronal maturation in oligodendrocyte-enriched cortical organoidsSemantic proximity Read