Article
Single-cell transcriptomic reveals molecular diversity and developmental heterogeneity of human stem cell-derived oligodendrocyte lineage cells.
Nature communications - 28 Jan 2021
Chamling Xitiz, Kallman Alyssa, Fang Weixiang, Berlinicke Cynthia A, Mertz Joseph L, Devkota Prajwal, Pantoja Itzy E Morales, Smith Matthew D, Ji Zhicheng, Chang Calvin, Kaushik Aniruddha, Chen Liben, Whartenby Katharine A, Calabresi Peter A, Mao Hai-Quan, Ji Hongkai, Wang Tza-Huei, Zack Donald J
Abstract excerpt
Injury and loss of oligodendrocytes can cause demyelinating diseases such as multiple sclerosis. To improve our understanding of human oligodendrocyte development, which could facilitate development of remyelination-based treatment strategies, here we describe time-course single-cell-transcriptomic analysis of developing human stem cell-derived oligodendrocyte-lineage-cells (hOLLCs). The study includes hOLLCs...
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