Article

Efficient generation of human oligodendrocyte grafts that restore myelin in adult human brain tissue

2026-08-25

Abstract excerpt

<title>Abstract</title> <p> Intracerebral transplantation of stem cell-derived oligodendrocytes (OLs) is a promising strategy for repairing demyelinated human brain tissue, the main hallmark of white-matter disorders. However, several challenges hinder clinical translation, including slow or inefficient production of human OLs with current protocols, and difficulty in generating pure OL grafts capable of remyeli...

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Literature Corpus work: c18f5c6b-2832-5081-9773-7c4df0901bd4
DOI: 10.21203/rs.3.rs-10248312/v1

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