Article

Stage-specific exposure to an activity-permissive media enhances neuronal maturation in oligodendrocyte-enriched cortical organoids

2026-05-18

Abstract excerpt

<h4>Summary</h4> Oligodendrocyte-enriched cortical organoids (OCOs) are a powerful platform for modeling oligodendrogenesis in a human cellular context. However, neuronal activity is impaired in conventional culture media, limiting assessment of neuronal function in conjunction with oligodendrocyte biology. To address this, we used a modified BrainPhys medium termed neuronal activity medium (NAM) and defined the...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b899bf00-08ee-5c09-81f4-c74fc509376f
DOI: 10.64898/2026.05.17.725797

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stage-specific exposure to an activity-permissive media enhances neuronal maturation in oligodendrocyte-enriched cortical organoidsDOI 10.64898/2026.05.17.725797Read

A novel approach to increase glial cell populations in brain microphysiological systemsSemantic proximity Read

Human spinal cord organoids recapitulate developmental and disease-associated oligodendrocyte lineage signaturesSemantic proximity Read

Generation of Bioengineered Neuronal Organoids (BENOs) from human pluripotent stem cellsSemantic proximity Read

DEVELOPMENT OF ORGANOID BASED MODEL TO STUDY IMMUNE-NEURAL INTERACTIONS IN HUMAN CNS DISEASESSemantic proximity Read

Validation of non-destructive morphology-based selection of cerebral cortical organoids by paired morphological and single-cell RNA-seq analysesSemantic proximity Read

Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and DiseaseSemantic proximity Read

Generation of human cerebral organoids with a structured outer subventricular zoneSemantic proximity Read

Long-term co-maturation of stem cell-derived microglia and neuronal networks: an optimized platform to assess human microglial contribution to neuronal functionSemantic proximity Read

Human Myelin Spheres for <i>In Vitro</i> Oligodendrocyte Maturation, Myelination and Neurological Disease ModelingSemantic proximity Read

Diversity of Adult Neural Stem and Progenitor Cells in Physiology and DiseaseSemantic proximity Read

Unified Generation of Regionalized Neural Organoids from Single-Lumen NeuroepitheliumSemantic proximity Read

Human Neural Organoid Microphysiological Systems Show the Building Blocks Necessary for Basic Learning and MemorySemantic proximity Read