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Article

Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA.

Nucleic acids research - 27 Feb 2015

Jayaprakash Anitha D, Benson Erica K, Gone Swapna, Liang Raymond, Shim Jaehee, Lambertini Luca, Toloue Masoud M, Wigler Mike, Aaronson Stuart A, Sachidanandam Ravi

Abstract excerpt

Eukaryotic cells carry two genomes, nuclear (nDNA) and mitochondrial (mtDNA), which are ostensibly decoupled in their replication, segregation and inheritance. It is increasingly appreciated that heteroplasmy, the occurrence of multiple mtDNA haplotypes in a cell, plays an important biological role, but its features are not well understood. Accurately determining the diversity of mtDNA has been difficult, due to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25653158
DOI: 10.1093/nar/gkv052
PMCID: PMC4344500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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