Article

Stable heteroplasmy at the single cell level is facilitated by inter-cellular exchange of mtDNA

2014-07-10

Abstract excerpt

Eukaryotic cells carry two genomes, nuclear (nDNA) and mitochondrial (mtDNA), which are ostensibly decoupled in their replication, segregation and inheritance. It is increasingly appreciated that heteroplasmy, the occurrence of multiple mtDNA haplotypes in a cell, plays an important biological role, but its features are not well understood. Accurately determining the diversity of mtDNA has been difficult, due to t...

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Literature Corpus work: b0426f6b-f971-587d-bbd3-0eec5aee1009
DOI: 10.1101/007005

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