Article

A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia

2026-02-14

Abstract excerpt

The basal ganglia (BG) underlie motor control, reward processing, and many neurological and psychiatric disorders, but a comprehensive epigenomic and 3D-genome atlas of the human BG is lacking. Here we present a multimodal single-cell atlas profiling DNA methylation and 3D chromatin conformation in 261,331 nuclei (snm3C-seq) across eight subregions, resolving 12 classes, 31 subclasses, and 59 groups. Harmonized un...

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Literature Corpus work: efb75499-d07e-5020-a33e-ff795dc4f370
DOI: 10.64898/2026.02.12.705594

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