Article

An overlooked distal regulatory signal on a shared haplotype drives the neuroinflammatory cascade underlying <i>GBA1</i> -associated Parkinson’s disease

2026-07-13

Abstract excerpt

<h4>BACKGROUND</h4> The persistent puzzle of how GBA1 coding variants underlying monogenic Gaucher disease confer such strong risk for polygenic Parkinson’s disease (PD) remains unresolved. Here, we sought to resolve this long-standing paradox. <h4>METHODS</h4> Using the Parkinson’s Progression Markers Initiative resource, we integrated whole-genome sequencing from sporadic PD cases and controls with matched t...

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Literature Corpus work: 0e55daf4-34e3-5d8f-bd6d-90463a12d0e0
DOI: 10.64898/2026.07.10.737850

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