Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair

22 Sept 2011

Abstract excerpt

The sirtuin gene family comprises an evolutionarily ancient set of NAD+ dependent protein deacetylase and mono-ADP ribosyltransferase enzymes. Found in all domains of life, sirtuins regulate a diverse array of biological processes, including DNA repair, gene silencing, apoptosis and metabolism. Studies in multiple model organisms have indicated that sirtuins may also function to extend lifespan and attenuate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to PARP inhibition in cancer therapy
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21946623
DOI: 10.18632/aging.100389

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repairPMID 21946623Read ↗

SIRT6, a Mammalian Deacylase with Multitasking AbilitiesSemantic proximity Read ↗

DNA stimulates SIRT6 to mono-ADP-ribosylate proteins within histidine repeatsSemantic proximity Read ↗

Emerging roles of SIRT6 in human diseases and its modulatorsSemantic proximity Read ↗

Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulatorsSemantic proximity Read ↗

Sirtuins, Metabolism, and CancerSemantic proximity Read ↗

The Histone Deacetylase SIRT6: At the Crossroads Between Epigenetics, Metabolism and DiseaseSemantic proximity Read ↗

Current role of mammalian sirtuins in DNA repairSemantic proximity Read ↗

The Biochemistry of SirtuinsSemantic proximity Read ↗

SIRT6Semantic proximity Read ↗

Long-lived mammals contain more phosphorylation sites in the SIRT6 C-terminus that enhance PARP1 interaction and resistance to oxidative stressSemantic proximity Read ↗

Sirtuins in metabolism, DNA repair and cancerSemantic proximity Read ↗

Sirtuins, metabolism, and DNA repairSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.