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Article

The Histone Deacetylase SIRT6: At the Crossroads Between Epigenetics, Metabolism and Disease

3 Dec 2013

Abstract excerpt

SIRT6 is one of the seven members of the NAD-dependent family of sirtuins mammals. The pleotropic identity of SIRT6 is manifested into several catalytic activities such as deacetylation, deacylation and ribosylation, which allow the targeting of a variety of protein substrates, that influence the physiology of multiple cell types and tissues. SIRT6- dependent deacetylation of histone H3 at lysines 9 and 56 is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24171769
DOI: 10.2174/15680266113136660213

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