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SIRT6, a Mammalian Deacylase with Multitasking Abilities

22 Aug 2019

Abstract excerpt

Mammalian sirtuins have emerged in recent years as critical modulators of multiple biological processes, regulating cellular metabolism, DNA repair, gene expression, and mitochondrial biology. As such, they evolved to play key roles in organismal homeostasis, and defects in these proteins have been linked to a plethora of diseases, including cancer, neurodegeneration, and aging. In this review, we describe the...

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PMID: 31437090
DOI: 10.1152/physrev.00030.2018

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