Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulators

9 Jun 2020

Abstract excerpt

Sirtuin 6 (SIRT6) is a nuclear NAD 1 -dependent deacetylase of histone H3 that regulates genome stability and gene expression. However, nonhistone substrates and additional catalytic activities of SIRT6, including long-chain deacylation and mono-ADP-ribosylation of other proteins, have also been reported, but many of these noncanonical roles remain enigmatic. Genetic studies have revealed critical homeostatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Calcium signaling and nucleotide metabolism
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32518153
DOI: 10.1074/jbc.rev120.011438

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Biological and catalytic functions of sirtuin 6 as targets for small-molecule modulatorsPMID 32518153Read ↗

SIRT6, a Mammalian Deacylase with Multitasking AbilitiesSemantic proximity Read ↗

The Histone Deacetylase SIRT6: At the Crossroads Between Epigenetics, Metabolism and DiseaseSemantic proximity Read ↗

Emerging roles of SIRT6 in human diseases and its modulatorsSemantic proximity Read ↗

Sirtuin functions and modulation: from chemistry to the clinicSemantic proximity Read ↗

The Biochemistry of SirtuinsSemantic proximity Read ↗

The Two-Faced Role of SIRT6 in CancerSemantic proximity Read ↗

Sirt6 Deacetylase: A Potential Key Regulator in the Prevention of Obesity, Diabetes and Neurodegenerative DiseaseSemantic proximity Read ↗

Rejuvenating Sirtuins: The Rise of a New Family of Cancer Drug TargetsSemantic proximity Read ↗

The complex role of SIRT6 in carcinogenesisSemantic proximity Read ↗

The Role of Sirtuin 6 in the Deacetylation of Histone Proteins as a Factor in the Progression of Neoplastic DiseaseSemantic proximity Read ↗

SIRT6 Widely Regulates Aging, Immunity, and CancerSemantic proximity Read ↗

SIRT6Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.