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Article

SIRT6

1 Jul 2010

Abstract excerpt

Sirtuins are the mammalian homologs of the yeast histone deacetylase Sir2. In recent years, an ever-expanding picture has emerged indicating that these proteins (SIRT1-7) play broad functions in cellular stress resistance, genomic stability, energy metabolism, aging and tumorigenesis. Among members of this family, SIRT6 appears to have particular significance in regulating metabolism, DNA repair and lifespan. In...

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PMID: 21327158
DOI: 10.4161/trns.1.1.12143

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