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Article

The complex role of SIRT6 in carcinogenesis

30 Dec 2015

Abstract excerpt

SIRT6, a member of the mammalian sirtuins family, functions as a mono-ADP-ribosyl transferase and NAD(+)-dependent deacylase of both acetyl groups and long-chain fatty acyl groups. SIRT6 regulates diverse cellular functions such as transcription, genome stability, telomere integrity, DNA repair, inflammation and metabolic related diseases such as diabetes, obesity and cancer. In this review, we will discuss the...

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PMID: 26717993
DOI: 10.1093/carcin/bgv167

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