Article

Tracing cancer evolution and heterogeneity using Hi-C

2023-02-21

Abstract excerpt

<h4>ABSTRACT</h4> Chromosomal rearrangements can initiate and drive cancer progression, yet it has been challenging to evaluate their impact, especially in genetically heterogeneous solid cancers. To address this problem we developed HiDENSEC, a new computational framework for analyzing chromatin conformation capture in heterogeneous samples, which can infer somatic copy number alterations, characterize large-sca...

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Literature Corpus work: 56f2548d-fe3d-5a7e-b235-1a0bf6184f91
DOI: 10.1101/2023.02.20.529175

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