Article

Unscrambling cancer genomes via integrated analysis of structural variation and copy number

2020-12-04

Abstract excerpt

Complex somatic genomic rearrangement and copy number alterations (CNA) are hallmarks of nearly all cancers. Whilst whole genome sequencing (WGS) in principle allows comprehensive profiling of these events, biological and clinical interpretation remains challenging. We have developed LINX, a novel algorithm which allows interpretation of short-read paired-end WGS derived structural variant and CNA data by clusteri...

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Literature Corpus work: a424f9de-3b17-55e8-8dfd-5972043b6299
DOI: 10.1101/2020.12.03.410860

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