Article

Hi-C for genome-wide detection of enhancer-hijacking rearrangements in routine lymphoid cancer biopsies

2025-03-18

Abstract excerpt

Standard techniques for detecting genomic rearrangements in formalin-fixed paraffin-embedded (FFPE) biopsies have important limitations. We performed FFPE-compatible Hi-C on 44 clinical biopsies comprising large B-cell lymphomas (n=18), plasma cell neoplasms (n=14), and other diverse lymphoid cancers, identifying consistent topological differences between malignant B cell and plasma cell states. Hi-C detected expe...

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Identifiers and source

Literature Corpus work: 66cd128c-d4eb-576e-8028-52b9e5545a63
DOI: 10.1101/2025.03.15.643352

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