Article

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor

2020-12-09

Abstract excerpt

The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that couples the binding of extracellular ligands, such as EGF and transforming growth factor- α (TGF-α), to the initiation of intracellular signaling pathways. EGFR binds to EGF and TGF- α with similar affinity but generates different signals from these ligands. To address the mechanistic basis of this phenomenon, we have carried out cryo...

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Literature Corpus work: 56e6b95f-157f-5599-b4ba-54b0f0e96ff0
DOI: 10.1101/2020.12.08.417006

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