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Article

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization.

Molecular cell - 1 Feb 2003

Ferguson Kathryn M, Berger Mitchell B, Mendrola Jeannine M, Cho Hyun Soo, Leahy Daniel J, Lemmon Mark A

Abstract excerpt

Epidermal growth factor (EGF) receptor is the prototype of the ErbB (HER) family receptor tyrosine kinases (RTKs), which regulate cell growth and differentiation and are implicated in many human cancers. EGF activates its receptor by inducing dimerization of the 621 amino acid EGF receptor extracellular region. We describe the 2.8 A resolution crystal structure of this entire extracellular region (sEGFR) in an...

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Source

Identifiers

PMID: 12620237
DOI: 10.1016/s1097-2765(03)00047-9

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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