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Article

The role of kinase domain dimerization in EGFR activation.

Structure (London, England : 1993) - 5 Mar 2026

Petrova Zaritza O, Han Long, Tsutsui Yuko, Sheetz Joshua B, Ashtekar Kumar D, Lemmon Mark A

Abstract excerpt

The epidermal growth factor receptor (EGFR) was among the first receptor tyrosine kinases (RTKs) shown to be activated by ligand-induced dimerization. Structural studies explain how ligand binding induces the dimerization of EGFR's extracellular region. Unlike other RTKs, EGFR's intracellular tyrosine kinase domain (TKD) is activated allosterically in an asymmetric dimer that is observed crystallographically, but...

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Identifiers

PMID: 41421344
DOI: 10.1016/j.str.2025.11.017
PMCID: PMC12731945

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

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