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Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The “Rotation Model”

2 Jun 2017

Abstract excerpt

The epidermal growth factor receptor (EGFR) plays vital roles in cellular processes including cell proliferation, survival, motility, and differentiation. The dysregulated activation of the receptor is often implicated in human cancers. EGFR is synthesized as a single-pass transmembrane protein, which consists of an extracellular ligand-binding domain and an intracellular kinase domain separated by a single...

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PMID: 28574446
DOI: 10.3390/cells6020013

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