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Article

Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor.

Nature structural & molecular biology - 7 Aug 2011

Mi Li-Zhi, Lu Chafen, Li Zongli, Nishida Noritaka, Walz Thomas, Springer Timothy A

Abstract excerpt

To our knowledge, no structural study to date has characterized, in an intact receptor, the coupling of conformational change in extracellular domains through a single-pass transmembrane domain to conformational change in cytoplasmic domains. Here we examine such coupling, and its unexpected complexity, using nearly full-length epidermal growth factor receptor (EGFR) and negative-stain EM. The liganded, dimeric...

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Identifiers

PMID: 21822280
DOI: 10.1038/nsmb.2092
PMCID: PMC4117315

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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