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Article

Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias.

Nature - 1 Feb 2022

Hu Chun, Leche Carlos A, Kiyatkin Anatoly, Yu Zhaolong, Stayrook Steven E, Ferguson Kathryn M, Lemmon Mark A

Abstract excerpt

The epidermal growth factor receptor (EGFR) is frequently mutated in human cancer1,2, and is an important therapeutic target. EGFR inhibitors have been successful in lung cancer, where mutations in the intracellular tyrosine kinase domain activate the receptor1, but not in glioblastoma multiforme (GBM)3, where mutations occur exclusively in the extracellular region. Here we show that common extracellular GBM...

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Identifiers

PMID: 35140400
DOI: 10.1038/s41586-021-04393-3
PMCID: PMC8857055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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