Article

Allosteric activation of preformed EGF receptor dimers by a single ligand binding event

2021-06-10

Abstract excerpt

<title>Abstract</title> <p>Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated in a variety of human cancers. Elucidation of the structure of the full-length receptor is essential to understand the molecular mechanisms underlying its activation. Unlike previously anticipated, here, we report that purified full-length EGFR adopts a homodimeric form <italic>in vitro</...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c9b1c505-22e3-5a1c-b239-af41c3447be4
DOI: 10.21203/rs.3.rs-182557/v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Allosteric activation of preformed EGF receptor dimers by a single ligand binding eventDOI 10.21203/rs.3.rs-182557/v2Read

The role of kinase domain dimerization in EGFR activation.Semantic proximity Read

Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The “Rotation Model”Semantic proximity Read

Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The “Rotation Model”Semantic proximity Read

Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor.Semantic proximity Read

Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor.Semantic proximity Read

A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptorSemantic proximity Read

EGF activates its receptor by removing interactions that autoinhibit ectodomain dimerization.Semantic proximity Read

Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers.Semantic proximity Read

Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling.Semantic proximity Read

The antibody zalutumumab inhibits epidermal growth factor receptor signaling by limiting intra- and intermolecular flexibility.Semantic proximity Read

EGFR Oncogenes Expressed In Glioblastoma Are Activated As Covalent Dimers And Paradoxically Stimulated By ErlotinibSemantic proximity Read

Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain.Semantic proximity Read