Article

Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The “Rotation Model”

2017-05-30

Abstract excerpt

The epidermal growth factor receptor (EGFR) plays vital roles in cellular processes including cell proliferation, survival, motility and differentiation. Dysregulated activation of the receptor is often implicated in human cancers. EGFR is synthesized as a single-pass transmembrane protein, which consists of an extracellular ligand-binding domain and an intracellular kinase domain separated by a single transmembra...

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Literature Corpus work: 434886a2-d762-563f-bda7-0fcf75e12f2c
DOI: 10.20944/preprints201705.0212.v1

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