Article

Modeling allele-specific gene expression by single-cell RNA sequencing

2017-02-17

Abstract excerpt

Allele-specific expression is traditionally studied by bulk RNA sequencing, which measures average expression across cells. Single-cell RNA sequencing (scRNA-seq) allows the comparison of expression distribution between the two alleles of a diploid organism and thus the characterization of allele-specific bursting. We propose SCALE to analyze genome-wide allele-specific bursting, with adjustment of technical varia...

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Literature Corpus work: f6420c29-543b-5acb-98b4-7d745efbbaf7
DOI: 10.1101/109629

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