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Article

SCALE: modeling allele-specific gene expression by single-cell RNA sequencing.

Genome biology - 26 Apr 2017

Jiang Yuchao, Zhang Nancy R, Li Mingyao

Abstract excerpt

Allele-specific expression is traditionally studied by bulk RNA sequencing, which measures average expression across cells. Single-cell RNA sequencing allows the comparison of expression distribution between the two alleles of a diploid organism and the characterization of allele-specific bursting. Here, we propose SCALE to analyze genome-wide allele-specific bursting, with adjustment of technical variability....

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Identifiers

PMID: 28446220
DOI: 10.1186/s13059-017-1200-8
PMCID: PMC5407026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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