Article

Using the simple telegraph model to decipher transcriptional burst regulation across genome-wide data

2025-10-30

Abstract excerpt

Gene transcription is a stochastic bursting process, with burst frequency and burst size as core parameters. Deciphering its genome-wide regulation is challenging, as complex models (capturing detailed biology) are impractical for large-scale use due to unstable inference and high computation. We proposed a simple telegraph model-based framework to analyze genome-wide scRNA-seq and smFISH datasets, addressing thes...

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Literature Corpus work: dc2f8b81-a5e1-5575-af20-99e0ce5097da
DOI: 10.1101/2025.10.29.685305

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