Epigenetic fluctuations underlie gene expression timescales and variability.

Abstract excerpt

Isogenic populations of mammalian cells exhibit significant gene expression variability. This variability can be separated into two components. Variance arises from events specific to the transcribed gene (i.e., cis or allele-specific sources) and variance from events that impact many genes at once (i.e., trans and global processes). Furthermore, the activity of the different regulatory factors that influence...

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