Article

Metabolic signature and proteasome activity controls synovial migration of<i>CDC42<sup>hi</sup></i>CD14<sup>+</sup>cells in rheumatoid arthritis

2023-06-16

Abstract excerpt

<h4>Summary</h4> <h4>Objective</h4> Activation of Rho-GTPases in macrophages causes inflammation and severe arthritis in mice. In this study, we explore if Rho-GTPases define the joint destination of pathogenic leukocytes in rheumatoid arthritis (RA) and how JAK inhibition mitigates these effects. <h4>Methods</h4> CD14 + cells of 136 RA patients were characterized by RNA-sequencing, and cytokine measurement to ide...

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Literature Corpus work: 56a174e7-020a-5d1d-86c8-e1b30e6fec83
DOI: 10.1101/2023.06.15.23291416

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