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Article

Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors.

Cell reports - 2 Nov 2021

He Lizhi, Jhong Jhih-Hua, Chen Qi, Huang Kai-Yao, Strittmatter Karin, Kreuzer Johannes, DeRan Michael, Wu Xu, Lee Tzong-Yi, Slavov Nikolai, Haas Wilhelm, Marneros Alexander G

Abstract excerpt

Macrophages undergoing M1- versus M2-type polarization differ significantly in their cell metabolism and cellular functions. Here, global quantitative time-course proteomics and phosphoproteomics paired with transcriptomics provide a comprehensive characterization of temporal changes in cell metabolism, cellular functions, and signaling pathways that occur during the induction phase of M1- versus M2-type...

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Identifiers

PMID: 34731634
DOI: 10.1016/j.celrep.2021.109955
PMCID: PMC8783961

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