Article

Integrative Analysis of Single-cell and Bulk RNA Sequencing Reveals Macrophage Heterogeneity in Lyme Arthritis

2025-02-19

Abstract excerpt

<h4>Introduction</h4> Lyme arthritis (LA) is a common late-stage manifestation of Lyme disease caused by Borrelia burgdorferi (Bb) infection. Macrophages play a crucial role in LA pathogenesis, yet their heterogeneity and functional states within the arthritic microenvironment remain poorly understood. <h4>Methods</h4> We integrated single-cell RNA sequencing data from ankle joint tissues of Bb-infected C57BL/...

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Literature Corpus work: 30ac43ce-517e-5917-b20a-58f67a73df43
DOI: 10.1101/2025.02.14.638349

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