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Article

GM-CSF potentiates macrophages to retain an inflammatory feature from their circulating monocyte precursors in rheumatoid arthritis.

Journal of translational medicine - 7 Aug 2025

Chen Jianing, Zhan Minghua, Zhao Yanling, Xu Honglin, Feng Futai, Bai Zhou, Zhang Ke, Fu Lufan, Wang Fang, Cheng Yongjing, Zhang Xuan, Liu Yudong

Abstract excerpt

OBJECTIVES: Peripheral monocytes represent an important source of macrophages in the synovium of rheumatoid arthritis (RA). However, it remains unclear whether the proinflammatory traits in RA monocytes can be maintained during their differentiation into macrophages without exogenous polarization stimuli. METHODS: Peripheral blood CD14+ monocytes from RA patients and healthy controls (HCs) were differentiated...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Granulocyte-Macrophage Colony-Stimulating Factor

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Source

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Identifiers

PMID: 40775724
DOI: 10.1186/s12967-025-06911-7
PMCID: PMC12330116

Genes

CCL22
CRP
CD14
CD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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