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Article

Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset

25 Sept 2024

Abstract excerpt

This study performed an in-depth investigation into the myeloid cellular landscape in the synovium of patients with rheumatoid arthritis (RA), “individuals at risk” of RA, and healthy controls (HC). Flow cytometric analysis demonstrated the presence of a CD40-expressing CD206 + CD163 + macrophage population dominating the inflamed RA synovium, associated with disease activity and treatment response. In-depth RNA...

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PMID: 39321281
DOI: 10.1126/sciadv.adj1252

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