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Mechanisms and functions of the macrophage metabolism-immune regulation axis in osteoarthritis - based on the JUN/ATG7 subtyping model from single-cell sequencing

2026-05-18

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<title>Abstract</title> <p>Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by dysregulation of the joint immune microenvironment, in which macrophages play a pivotal role. This study aimed to elucidate the mechanisms by which macrophage mitochondrial function regulates immune phenotypes to drive OA progression. Through integrated analysis of single-cell RNA sequencing and bulk transcri...

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Literature Corpus work
bec97f1f-4118-58cb-a552-7e144fd8ba3f
DOI
10.21203/rs.3.rs-9608356/v1
Open publication

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Mechanisms and functions of the macrophage metabolism-immune regulation axis in osteoarthritis - based on the JUN/ATG7 subtyping model from single-cell sequencingDOI 10.21203/rs.3.rs-9608356/v1
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