Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma.

doi:10.1038/s43018-026-01179-2

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Article

Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma.

Nature cancer - 1 Jun 2026

Ghannam Jack Y, Bryan Julian, Weiss Jakob, Kovarsky Daniel, Merrell David, Messer Conor, Schlueter-Kuck Kristy, Fell Geoffrey G, Lim-Fat Mary Jane, Youssef Gilbert, Rahman Rifaquat, Qin Lei, Young Geoffrey S, Janes J Thomas, Van Orden McKayla, Pfaff Kathleen L, Gans Andrew, Lin Emma S, Huang Raymond Y, Danysh Brian P, Parida Laxmi, Li Shuqiang, Wen Patrick Y, Chiocca E Antonio, Neuberg Donna, Ligon Keith L, Tirosh Itay, Reardon David A, Getz Gad, Wu Catherine J

Abstract excerpt

The determinants of immune checkpoint blockade (ICB) response in glioblastoma (GBM) with wild-type isocitrate dehydrogenase remain poorly understood. Here we profiled 181 ICB-treated GBM cases using bulk DNA sequencing, bulk RNA sequencing and single-nucleus RNA sequencing to investigate the genomic features associated with ICB outcomes. Baseline tumor transcriptional subtype was predictive of overall survival...

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Identifiers

PMID: 42237038
DOI: 10.1038/s43018-026-01179-2

Genes

CDKN2A
PDGFRA

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