Article

Transcriptional Plasticity and Platform-Specific Immune Targetability in IDH-Wildtype Glioblastoma

2026-07-30

Abstract excerpt

IDH-wildtype glioblastoma contains coexisting developmental and injury-associated malignant cell states whose proportions are shaped by genotype, microenvironment and treatment. This plasticity influences immune targetability, but the relevant biological gates differ across therapeutic platforms. Mutation-directed vaccines and T-cell receptor therapies require sufficient cancer-cell coverage, mutant-allele express...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 532fd7c6-220e-5f2f-b9f7-1d1dad40b4ea
DOI: 10.20944/preprints202310.0607.v2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptional Plasticity and Platform-Specific Immune Targetability in IDH-Wildtype GlioblastomaDOI 10.20944/preprints202310.0607.v2Read

Tumoral and immune heterogeneity in an anti-PD-1-responsive glioblastoma: a case study.Semantic proximity Read

New hints towards a precision medicine strategy for IDH wild-type glioblastoma.Semantic proximity Read

Multiomics and spatial mapping characterizes human CD8 + T cell states in cancerSemantic proximity Read

Mapping kinase-dependent tumor immune adaptation with multiplexed single-cell CRISPR screensSemantic proximity Read

Immunogenomic, single-cell and spatial dissection of CD8 <sup>+</sup> T cell exhaustion reveals critical determinants of cancer immunotherapySemantic proximity Read

Deep immune profiling reveals targetable mechanisms of immune evasion in checkpoint blockade-refractory glioblastomaSemantic proximity Read

Comparative cross-methodological analysis of the IDH-wildtype glioblastoma tumor microenvironment.Semantic proximity Read

Dual checkpoint blockade of glioblastoma with Anti-PD-1 and Anti-LAG-3 promotes expansion of tumor-reactive T cell clones along a unique pathway of differentiationSemantic proximity Read

Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastomaSemantic proximity Read

Tumor Immune Evasion: Hiding as “Cold” Tumors and Resisting as “Hot” TumorsSemantic proximity Read

Characterization of the minimal residual disease state reveals distinct evolutionary trajectories of human glioblastomaSemantic proximity Read

A Tonic Signaling Code Predicts CAR-T Cell Efficacy in Diffuse Midline GliomaSemantic proximity Read