Article

DNA-PKcs inhibition sensitizes glioblastoma to radiotherapy through reprogramming of tumor cell states and immune microenvironment cell types

2026-06-05

Abstract excerpt

<title>Abstract</title> <p>Glioblastoma is the most common malignant brain tumor in adults, and radiotherapy (RT) is the most effective postoperative treatment for patients with glioblastoma. Nevertheless, glioblastoma recurrence after treatment is nearly universal, and cell state plasticity and intratumor heterogeneity underlie glioblastoma evolution and resistance to treatment. Here we integrate in vitro genome...

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Literature Corpus work: fc887a54-05f5-5b82-b95b-a97e4b2177b6
DOI: 10.21203/rs.3.rs-9657955/v1

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