Article

Subtype-Specific Dependencies and Drug Vulnerabilities Enable Precision Therapeutics in Head and Neck Cancer

2025-12-09

Abstract excerpt

<h4>ABSTRACT</h4> Molecular heterogeneity in head and neck squamous cell carcinoma (HNSCC) is well recognized, yet existing subtype frameworks remain largely descriptive and have not translated into therapeutic decision-making. Here, we establish a mechanistic platform that converts transcriptomic diversity into drug-actionable tumor states. Integrating multi-cohort RNA-seq from 727 tumors across five independent...

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Literature Corpus work: 730fcf08-2f55-54be-b08a-b28ccc205b7a
DOI: 10.64898/2025.12.05.692684

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