Article

Notch induces transcription by stimulating release of paused RNA Pol II without increasing chromatin accessibility

2024-06-13

Abstract excerpt

Notch proteins undergo ligand-induced proteolysis to release a nuclear effector that influences a wide range of cellular processes by regulating transcription. Despite years of study, however, how Notch induces the transcription of its target genes remains unclear. Here, we comprehensively examined the response to human Notch1 across a time course of activation using high-resolution genomic assays of chromatin acc...

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Literature Corpus work: 5655c413-8ddb-5d76-85c5-1ce5f4bb6494
DOI: 10.1101/2024.06.13.598853

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