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Article

Modifiers of notch transcriptional activity identified by genome-wide RNAi.

BMC developmental biology - 19 Oct 2010

Mourikis Philippos, Lake Robert J, Firnhaber Christopher B, DeDecker Brian S

Abstract excerpt

BACKGROUND: The Notch signaling pathway regulates a diverse array of developmental processes, and aberrant Notch signaling can lead to diseases, including cancer. To obtain a more comprehensive understanding of the genetic network that integrates into Notch signaling, we performed a genome-wide RNAi screen in Drosophila cell culture to identify genes that modify Notch-dependent transcription. RESULTS: Employing...

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Identifiers

PMID: 20959007
DOI: 10.1186/1471-213X-10-107
PMCID: PMC2976970

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Source receipt: pubmed, retrieved 7 Sept 2026.

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