Article

Massively Parallel Profiling of RNA-targeting CRISPR-Cas13d

2023-03-28

Abstract excerpt

<h4>ABSTRACT</h4> Type VI CRISPR enzymes cleave target RNAs and are widely used for gene regulation, RNA tracking, and diagnostics. However, a systematic understanding of their RNA binding specificity and cleavage activation is lacking. Here, we describe RNA c hip- h ybridized a ssociation- m apping p latform (RNA-CHAMP), a massively parallel platform that repurposes next-generation DNA sequencing chips to m...

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Literature Corpus work: 53161252-efdb-5441-b3a7-6e5a5fc77d22
DOI: 10.1101/2023.03.27.534188

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