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Effective macrophage clearance of <i>Klebsiella pneumoniae</i> requires the inducible nitric oxide synthase iNOS and is independent of reactive oxygen species generated by NADPH oxidase

2026-05-18

Abstract excerpt

Klebsiella pneumoniae is a leading cause of pneumonia and bacteremia and is especially dangerous in healthcare settings. Despite massive clinical significance, the mechanisms used by macrophages to kill K. pneumoniae are not well defined. Macrophages are critical for controlling K. pneumoniae as mice lacking monocyte-derived or alveolar macrophages have higher bacterial tissue burdens and mortality. Two prominen...

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Literature Corpus work
5628c648-e458-5d19-9f2c-f3a876ac1a34
DOI
10.64898/2026.05.14.724925
Open publication

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Effective macrophage clearance of <i>Klebsiella pneumoniae</i> requires the inducible nitric oxide synthase iNOS and is independent of reactive oxygen species generated by NADPH oxidaseDOI 10.64898/2026.05.14.724925
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