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Atg7 deficiency impairs host defense against <i>Klebsiella pneumoniae</i> by impacting bacterial clearance, survival and inflammatory responses in mice

4 Jul 2014

Abstract excerpt

Klebsiella pneumoniae (Kp) is a Gram-negative bacterium that can cause serious infections in humans. Autophagy-related gene 7 (Atg7) has been implicated in certain bacterial infections; however, the role of Atg7 in macrophage-mediated immunity against Kp infection has not been elucidated. Here we showed that Atg7 expression was significantly increased in murine alveolar macrophages (MH-S) upon Kp infection,...

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PMID: 24993132
DOI: 10.1152/ajplung.00046.2014

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