Article
Nitrite Derived from Endogenous Bacterial Nitric Oxide Synthase Activity Promotes Aerobic Respiration.
mBio - 1 Aug 2017
Chaudhari Sujata S, Kim Minji, Lei Shulei, Razvi Fareha, Alqarzaee Abdulelah A, Hutfless Elizabeth H, Powers Robert, Zimmerman Matthew C, Fey Paul D, Thomas Vinai C
Abstract excerpt
Macrophage-derived nitric oxide (NO·) is a crucial effector against invading pathogens. Yet, paradoxically, several bacterial species, including some pathogens, are known to endogenously produce NO· via nitric oxide synthase (NOS) activity, despite its apparent cytotoxicity. Here, we reveal a conserved role for bacterial NOS in activating aerobic respiration. We demonstrate that nitrite generated from endogenous...
Topics
- Aerobiosis
- Bacterial Proteins
- Electron Transport Complex IV
- Mutation
- Nitric Oxide
- Nitric Oxide Synthase
- Nitrites
- Oxidation-Reduction
- Oxidative Stress
- Oxidoreductases
- Repressor Proteins
- Staphylococcus aureus