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Nitric Oxide Detoxification Systems Enhance Survival of <i>Neisseria meningitidis</i> in Human Macrophages and in Nasopharyngeal Mucosa

20 May 2005

Abstract excerpt

Nitric oxide (NO) contributes to mammalian host defense by direct microbicidal activity and as a signaling molecule of innate immune responses. Macrophages produce NO via the inducible NO synthase (iNOS). The genome of Neisseria meningitidis includes two genes, norB (encoding nitric oxide reductase) and cycP (encoding cytochrome c'), both of which detoxify NO in pure cultures of N. meningitidis. We show here that...

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PMID: 15908358
DOI: 10.1128/iai.73.6.3322-3329.2005

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Nitric Oxide Detoxification Systems Enhance Survival of <i>Neisseria meningitidis</i> in Human Macrophages and in Nasopharyngeal MucosaPMID 15908358Read ↗

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