Article

Increased Neutrophil H2O2 Production and Enhanced Pulmonary Clearance of Klebsiella pneumoniae in G6PD A- Mice

2024-03-11

Abstract excerpt

<title>Abstract</title> <p>The X-linked A<sup>-</sup> variant (rs1050828, Val68Met) in <italic>G6PDX </italic>accounts for glucose-6-phosphate (G6PD) deficiency in approximately 11% of African American males. This common, hypomorphic variant may impact pulmonary host defense and phagocyte function during pneumonia by altering levels of reactive oxygen species produced by host leukocytes. We used CRISPR-Cas9 techn...

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Literature Corpus work: 01d188db-34d7-5bd2-aad5-e0233023befc
DOI: 10.21203/rs.3.rs-3931558/v1

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