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Lactate Oxidase (LctO) Acts as a Metabolic Checkpoint Restraining <i>Streptococcus pneumoniae</i> Invasion of Respiratory Epithelial Barriers

2026-07-17

Abstract excerpt

Streptococcus pneumoniae rapidly translocates across polarized human bronchial epithelial barriers, with viable bacteria recovered from the basolateral compartment within 1 h post-infection. Disruption of the pyruvate node through combined deletion of pyruvate oxidase ( spxB ) and lactate oxidase ( lctO ) markedly enhanced transmigration of S. pneumoniae across polarized Calu-3 monolayers without causing early...

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Literature Corpus work
97a98d64-65dd-55cc-ba12-2a4c2421f6d9
DOI
10.64898/2026.07.15.738724
Open publication

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Lactate Oxidase (LctO) Acts as a Metabolic Checkpoint Restraining <i>Streptococcus pneumoniae</i> Invasion of Respiratory Epithelial BarriersDOI 10.64898/2026.07.15.738724
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