Back to search

Article

Functional Phenotyping of MMV Pandemic Response Box Identifies Stage-specific inhibitors Against Blood stage <i>Plasmodium</i>

2024-10-08

Abstract excerpt

<h4>ABSTRACT</h4> Wide-spread resistance to clinically used antimalarials necessitates the prioritization of novel scaffolds with alternate mechanisms, as possible partner drugs to artemisinin. We utilized the Pandemic Response Box chemical library of the Medicines for Malaria Venture launched in 2019 to identify inhibitors with stage-specific potency and phenotypic signatures against P. falciparum towards explo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
55a8441a-02d1-534b-9166-75e3310b624f
DOI
10.1101/2024.10.08.617232
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Functional Phenotyping of MMV Pandemic Response Box Identifies Stage-specific inhibitors Against Blood stage <i>Plasmodium</i>DOI 10.1101/2024.10.08.617232
Screening the Medicines for Malaria Venture Pathogen Box for invasion and egress inhibitors of the blood stage of <i>Plasmodium falciparum</i> reveals several inhibitory compoundsSemantic proximity
Whole Cell Phenotypic Screening Of MMV Pathogen Box identifies Specific Inhibitors of <i>Plasmodium falciparum</i> merozoite maturation and egressSemantic proximity
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response BoxSemantic proximity
A fast-acting inhibitor of blood-stage <i>P. falciparum</i> with mechanism distinct from artemisinin and chloroquineSemantic proximity
Identification of potent and selective <i>N</i> -myristoyltransferase inhibitors of <i>Plasmodium vivax</i> liver stage hypnozoites and schizontsSemantic proximity
Promising antimalarial hits from phenotypic screens: a review of recently-described multi-stage actives and their modes of actionSemantic proximity
Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage <i>Plasmodium falciparum</i> , using a nano luciferase reporter read-outSemantic proximity
A <i>Plasmodium vivax</i> controlled human infection and transmission model to evaluate interventions across the life cycleSemantic proximity
Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistanceSemantic proximity
Screening of a chemogenetic library unveils dual-stage antimalarials with low cytotoxicitySemantic proximity
Multistage and transmission-blocking tubulin targeting potent antimalarial discovered from the open access MMV Pathogen BoxSemantic proximity
Aryl N-acetamide compounds exert antimalarial activity by acting as agonists of rhomboid protease <i>Pf</i> ROM8 and cation channel <i>Pf</i> CSC1Semantic proximity
Select a neighboring publication to make it the new centre.